Haemotology involves the diagnosis and treatment blood and bone marrow disorders. These affect the production of blood and its components, such as blood cells, haemoglobin, blood proteins, and coagulation (clotting).
Examples of blood and bone marrow disorders include haemophilia, leukaemia, and sickle cell anaemia.
Severe Haemophilia A is a serious bleeding disorder affecting 2,000 people in the UK. Patients suffer spontaneous bleeding in their joints and muscles, and even their brain. Current treatment involves injecting coagulation Factor VIII (Factor 8) two to three times a week to control and prevent bleeding, which affects the patient’s quality of life and is expensive.
A study by our haemostasis research unit shows that adding another coagulation protein, Factor XIII (Factor 13), could significantly reduce the need for Factor VIII. A major advantage with Factor XIII is that it stays circulating in the blood for a long time, so patients would only needed to be injected once or twice a month.
Our researchers are now doing clinical trials. If they prove that Factor XIII is as good as or better than Factor VIII, it will improve quality of treatment and drastically cut the cost of treating haemophilia A by a (conservative) estimate of up to 25%, possibly within 5 years.
Read our news story
See the scientific paper
This is just a small amount of the research we do in this area. If you’re a patient interested in finding out more, then speak to your consultant at your next appointment. If you are not a patient at Guy’s and St Thomas’ then speak to your own consultant in the first instance.