The coronavirus infection in immunosuppressed children study is designed to allow families of immunosuppressed children and young people to self-record their experiences of coronavirus (COVID-19) and other viral respiratory illnesses during the coronavirus (COVID-19) epidemic. Parents of immunosuppressed patients, and young people aged 16-17 years who are immunosuppressed, will be provided with online information and asked to fill in online questionnaires at baseline and weekly thereafter.
Information collected will include immune system affecting medication, symptoms, contact with health care providers, test results and impact on daily activities. Data will be collected and analysed weekly to be able to monitor any potential risk factors for severe disease. This study is complementary to, and not overlapping with, the global ISARIC World Health Organisation protocol that will be studying coronavirus (COVID-19) cases admitted to all NHS Trusts, including all children.
So far we have very little information about how COVID-19 affects mothers and newborn babies and it is not clear how best to care for mothers and babies affected. We have very little information about how babies get COVID-19, whether it transmits from mothers to their baby(s) while they are still pregnant, during labour and birth, or whether the infection occurs following birth. Understanding this will mean that we can give the best care to mothers and babies and the best advice to pregnant women about the effects of COVID-19 on their baby.
This study will collect information about newborn babies who have COVID-19 or who are born to mothers who have Coronavirus. The information we collect will help us to understand:
- how babies get COVID-19
- what happens to babies when their mother has COVID-19
- What treatments are effective in helping babies with COVID-19 to get better
- What happens to babies when they have been treated.
We are carrying out the study through the British Paediatric Surveillance Unit (BPSU) system. Each week, every doctor across the UK looking after newborn babies in hospital will be asked by the BPSU if they have looked after a newborn baby with COVID-19 or whose mother has COVID-19. If they have, they will be sent a questionnaire to collect information about the baby and their mother. As this information about all affected babies is urgently needed, we will not be asking parents for consent to include their baby's information in the study, although parents will be able to opt out.
Pregnancy and neonatal outcomes in COVID-19
This study aims to better understand how COVID-19 affects early pregnancy, fetal growth, prematurity and virus transmission to the baby. The study will examine data from women with suspected and confirmed COVID-19 from early pregnancy to after delivery of the baby.
Find out more about the pregnancy and neonatal outcomes study on the NIHR website.
This NIHR supported study is a national study of women hospitalised with confirmed COVID-19 in pregnancy. The study, funded by the NIHR, will use the UK Obstetric Surveillance System (UKOSS) to collect information about all pregnant women admitted to hospital who are confirmed to have the virus infection. The information will be analysed on a continuous basis to inform ongoing guidance for women and maternity staff as we respond to the pandemic. More specifically, the study will describe incidence, management and outcomes of COVID-19 in pregnancy and identify factors associated with better outcomes for women and their babies.
Anonymous information will be collected through the existing UK Obstetric Surveillance System (UKOSS) reporters, who are based in all maternity units in the UK. Reporters have been sent a live link to allow them to notify cases and complete an anonymous data collection form.