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Ear, nose and throat and audiology

The ear, nose and throat (ENT) department at Guy's Hospital participates in various clinical research that helps in the treatment and management of ENT disorders. This includes diseases of the ear, nose and throat, as well as hearing and balance problems. These studies are supported by the National Institute for Health Research and commercial drug companies.

Trials looking for volunteers

We are currently looking for volunteers to take part in the following studies. Eligible participants will have to be diagnosed formally by their GP or doctor in hospital. If you are eligible and would like to participate, please email for more information.

  • MACRO: defining best management in adult
    chronic rhinosinusitis

    The MACRO trial is part of a large programme of work funded by the government. It aims to establish which treatments work best for adults with chronic rhinosinusitis (CRS) with and without nasal polyps.

    CRS is a long-term sinus disease affecting one in 10 adults in the UK. The MACRO trial will investigate three different treatment options for patients with CRS. All participants who join the MACRO trial will be asked to use standard care (intranasal medications), which are considered the current best practice for management of CRS.

    For more information visit the MACRO website or email us at

    Please ask your doctor to refer you to Guy's Hospital if you are interested in taking part.

  • NAIROS: nasal airway obstruction study

    The NAIROS trial wants to find out which treatment works better and which treatment should be used widely in the NHS. This study will investigate whether surgery (septoplasty) or medical management is the best method for treating problems with a blocked nose (nasal airway obstruction). 

    Patients who agree to take part are randomly allocated to either medical management or surgery. Information will be also be collected on health, quality of life, concerns, and costs to patients.

    For more information visit the NAIROS website or email us at

    Please ask your doctor to refer you to Guy's Hospital if you are interested in taking part.

  • OTONOMY – Meniere’s disease study

    The purpose of this study is to test the effectiveness (how well it works) and safety of an investigational product or drug, OTO-104, compared to a placebo (a ‘dummy drug’ ) in people with Meniere’s disease. OTO-104 contains an active ingredient, called dexamethasone, which is a commonly used corticosteroid (also commonly called a ‘steroid’).

    Email us at for more information.

    Please ask your doctor to refer you to Guy's Hospital if you are interested in taking part.

Ongoing studies

Read about ongoing studies. Please note we are no longer recruiting volunteers for these trials.

  • EVOTION 2020 – hearing loss

    EVOTION investigates self-management and learning from user patterns, auditory training, and prevention of noise-induced hearing loss. Researchers in the EVOTION project include hearing care professionals working in public and private clinics in the United Kingdom and in Greece, data and security scientists, and policy makers.

    The project will show how individual data from hearing aid users, pooled into a large data set, improves the outcomes of hearing healthcare for the individual users. Furthermore, EVOTION aims to lead to evidence-based practices and evidence-informed public health policies.

    The project uses open-source big data analysis tools to process the heterogeneous data coming from different vendors and domains as a first step towards open data and open research. The EVOTION project generates evidence to support integrated decision support in a platform for the creation of holistic hearing loss management policies.

    The project is funded by the European Commission Horizon 2020, has 13 partners from seven EU countries including Guy’s and St Thomas’ Hospital and is coordinated by Oticon (Denmark).

    For more information, visit the EVOTION 2020 website.
  • NATTINA – recurrent tonsillitis

    The role of tonsillectomy in the management of adult sore throat remains uncertain, and despite demonstrable compliance with Scottish Intercollegiate Guidelines Network (SIGN) guidance, UK regional variation in tonsillectomy rates persists.

    In the NATTINA study we want to investigate the effectiveness and costs of tonsillectomy compared with conservative management (deferred surgery) in adults with frequent sore throats.

    Participants are randomly split into two groups – surgery and conservative management. We plan to compare the number of sore throat days after each approach which may help us make better NHS guidance about who can benefit most from surgery.

    Visit the NATTINA website for more information and watch the information DVD.

  • SINUS-24 nasal polyp study

    The purpose of this study is to see how well and how safely a study drug called dupilumab works in people who have nasal polyps. The study compares dupilumab to a dummy drug (or ‘placebo’), and both treatments are given by an injection under the skin every two weeks for 24 weeks. These injections are given in addition to another medicine called ‘Nasonex’ nasal spray which contains the corticosteroid mometasone furoate. This medicine is used to control nasal polyps. This study is being sponsored by the pharmaceutical company, Sanofi.

  • SYNAPSE – nasal polyp study

    This is a study to assess the effect of mepolizumab in patients with severe bilateral nasal polyps, sponsored by GlaxoSmithKline (GSK). Mepolizumab is a type of medicine called a monoclonal antibody that is made in the laboratory; it works by blocking a specific protein in the body called interleukin-5, which people with severe nasal polyps can have more of in their body. This study will look at how people react to and how the body uses mepolizumab. Participants will be randomly split into two groups; the active drug and placebo (a ‘dummy pill’).

    The study drug, mepolizumab, is not approved yet for doctors to treat patients with nasal polyps, however it is for some patients with severe asthma in several countries.

Previous studies

Read about past studies. Please note we are no longer recruiting volunteers for these trials.

  • TACTT3/AMPACT2 – tinnitus study

    The purpose of this research study was to obtain further information about the safety and efficacy of a treatment with AM-101 (study drug) when administered into the middle ear for tinnitus.

  • OTONOMY – Meniere’s disease study

    The purpose of this study was to primarily test the effectiveness and safety of OTO-104 (study drug) compared to a placebo (a 'dummy pill') in participants with Meniere’s disease.