Success rates

 

Our Assisted Conception Unit (ACU) is proud of our history of offering both IVF and PGD. Over 1,000 babies have been born following PGD at Guy’s Hospital.

Success rates are published by the Human Fertilisation and Embryology Authority (HFEA). Overall, around 1 in 3 (33%) PGD cycles will result in a pregnancy which progresses to term. If there are healthy embryos created, this rises to 1 in 2 (50%) per embryo transferred. In other words, each embryo has a 1 in 2 (50%) chance of resulting in a pregnancy.

More detail about our success at each step of the PGD process is below:

PGD success rates 1997-Dec 2017

 

 Overall (1997-2017)

2013

2014

 2015

2016

2017

No of cycles

3,345

 254

350

 396

423

435

No of embryo transfers 

2,257

200 

265

 241

283

262

Clinical pregnancies

965

 73

96

 124

111

129

*CPR/cycle (%)

30%

 29%

28%

 33.5%

29%

29.5%

**CPR/ET (%)

46%

 37%

37%

 40%

46%

49%

*Clinical pregnancy rate (this is defined as a pregnancy that has been confirmed to have a fetal heartbeat on scan not just a positive pregnancy test).

Unfortunately not all couples who start a PGD cycle end up having embryos suitable for transfer. The further a couple progresses through a cycle, the better their chance of having a baby.

We continually aim to improve our success rates through research and regular reviews of our service. We feel that it is important to be honest and realistic and we acknowledge that sadly, we will not be able to achieve a pregnancy for some couples who undergo treatment with us. Whatever the outcome, we hope that the experience will be a positive one and we will give you as much support as possible throughout your treatment.

Find out what can affect the chance of success.

Chances of having a baby following PGD

Overall, the chance of a couple having a baby born following treatment is around 40% (this is based on an average of two cycles of PGD per couple). Your chances increase if you progress successfully through each step of the treatment process. Your chances of a clinical pregnancy (pregnancy with a heartbeat seen on ultrasound scan) per cycle are:

  • one in three, when you start a cycle
  • one in two if you have embryo(s) replaced.

Babies born 1997-July 2016

Singletons

592

Twins

162

Triplets

15

Total

769

Transferring an embryo

Starting a treatment cycle is no guarantee that there will be embryos suitable for transfer. Sometimes there may be no embryos to transfer for one or more of several reasons:

  • there may be very few, or no, eggs
  • some eggs may not fertilise
  • some embryos may not  grow enough to reach the testing stage
  • all embryos may be affected.

If you have a positive pregnancy test, there is still a risk that you may miscarry, or have an ectopic pregnancy (2%). Understandably, this can be disappointing and upsetting. As many couples requesting PGD are fertile, this may be one of the most difficult aspects of the treatment.

 

Patient stories

Hear from couples who have been successfully helped by our centre.

What can affect the chances of success?

Find out what can affect the chance of success.