Coronavirus update and advice: pre-implantation genetic diagnosis service
In response to the coronavirus (COVID-19) outbreak, please read our advice and information before attending the service.
Welcome to the pre-implantation genetic diagnosis (PGD) service at Guy's Hospital. We are committed to providing patient-led, quality care.
PGD has been offered at Guy's Hospital since 1997, and is the largest PGD centre in the UK and one of the most successful in Europe. We perform more than 60% of the PGD cycles carried out within the UK. We currently test for more than 300 genetic disorders, including cystic fibrosis, sickle cell disease, and Huntington disease. As of 2018, we have had over 1,000 babies born following successful PGD.
We are licenced by the Human Fertilisation and Fertility Authority (HFEA) to provide this specialist service, both through the NHS and privately.
What is PGD?
Pre-implantation genetic diagnosis (PGD) is a special type of in vitro fertilisation (IVF) which is available to couples who are at an increased risk of having a child with a specific genetic condition. The aim is to avoid passing on the genetic condition to the child.
In PGD, embryos are created outside of the body. They are genetically tested for the condition in the family. Only embryos which are not affected by the genetic condition are then placed back into the womb, where a pregnancy hopefully occurs. The process of PGD does not change the genes of the embryos and is not a form of gene editing.
Who is eligible for PGD? How do I get a referral?
NHS funding is available for couples who have at least a 10% chance of having a child with a specific genetic condition. To be eligible for NHS funding, the female partner must be under the age of 40 when treatment begins, and must also have a body mass index (BMI) of between 19 and 30. Both partners must be non-smokers (including e-cigarettes) and living at the same address. The couple cannot have a healthy, unaffected child together. If you do not meet this criteria, we can discuss self-funding and private options.
We are also happy to apply for NHS funding for single people and for same-sex couples. If sperm or egg donation is required, there may be an additional fee which is not covered by NHS funding. We can discuss this with you at your initial appointment.
To be referred to the PGD clinic at Guy’s Hospital, the person or couple must be first seen by their local clinical genetics service to review all the available reproductive options, and to have eligibility confirmed. If you are a healthcare professional find out how to make a referral.