We are based at Guy's Hospital. We are experts in the field of fertility and preimplantation genetic diagnosis (PGD).
Our aim is to provide you with information on what preimplantation genetic diagnosis is and how can it help you to achieve a pregnancy by avoiding the genetic condition known in your family.
We can offer PGD for:
- tissue typing to provide a bone marrow matched sibling for a sick child (known as HLA typing)
- fertilty preservation with PGD for those affected by an inherited form of cancer.
We are happy to consider PGD for other conditions not listed as it is usually possible to develop tests.
What is PGD?
Pre-implantation genetic diagnosis (PGD) is available to couples who are at risk of having a child with a specific genetic or chromosome disorder.
It involves the use of assisted reproductive technology (ART) which is also offered to couples with fertility problems, such as IVF and ICSI. The aim is to obtain and fertilise a number of eggs. Once fertilised, the embryos develop for five to six days and then a number of cells are removed from each embryo that has formed a blastocyst (this is called trophectoderm biopsy). The genetic material (DNA) from the embryos is then tested for the genetic or chromosome abnormality. If unaffected embryos are available, usually one embryo is then transferred into the womb with the hope that it will implant and form a pregnancy. If successful, the baby should be unaffected by the disorder it was tested for.
Step 1 Create the embryos, followed by biopsy and testing. Freeze all tested embryos. Step 2 Transfer of unaffected frozen embryo