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Antibody incompatible kidney transplant


Coronavirus: kidney and transplant update

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Sometimes a patient waiting to have a transplant has antibodies in their blood that would react against the kidney and damage it. These antibodies may be due to a previous transplant, pregnancy or blood transfusion and the patient is said to be 'sensitized'. 

Transplantation in these circumstances would result in severe rejection and potential loss of the kidney. However, it is possible to remove or suppress these antibodies in a process known as 'desensitization', which can allow the transplant to take place.

Our experience

A small number of centres in the UK are attempting to use 'desensitization'. We have transplanted over 50 previously 'sensitized' patients in the last few years, and have a one year graft survival of 85%, which compares well with international centres.

Our experience and success attracts referrals from all over the UK and beyond.

What we do

We have developed a particular interest in transplanting these immunologically complex patients. The process of 'desensitization' can involve a number of different techniques, including:

  • using drugs to inhibit antibody production
  • using additional drugs which suppress the immune system
  • removing antibodies (plasmapheresis and immunoabsorption) from the circulation.

Referral information

For further information about our programmes or to refer a patient, please contact Professor Nizam Mamode, lead clinician in antibody incompatible transplantation. Email