HIV research studies

A total of 88,769 people, including 315 children aged under 15, received HIV specialist care in the UK in 2015.

Over the last decade, the number of people accessing specialist care for HIV has steadily grown. Between 2006 to 2015, there has been a 73% increase in the number of people accessing HIV care.

The Harrison Wing conducts a variety of drug trials and observational studies. These studies aim to improve our understanding of HIV and discover better treatments. It is up to you whether you want to take part in research and it will not affect your care in any way.

A doctor or a research nurse will be very happy to give you more information and discuss your suitability for a trial. If you want us to let you know about the latest studies please contact us directly or sign up for the research letter.

Please telephone 020 7188 2608/9 to speak to the clinical trials unit or email

Trials looking for volunteers

We are currently looking for volunteers to take part in the following studies.

Click on the headings below to find out more about each study and see if you might eligible to take part and help us with our research.

  • Patients not on antiretroviral treatment

    Validate VALacyclovir in delaying antiretroviral treatment entry
    This study will investigate whether using daily valacyclovir, a very well tolerated treatment for herpes infection infection, can delay when you need to take lifelong antiretroviral therapy.

    Are you suitable? To take part in this study you must:

    • have a CD4 count between 400-900
    • not be on antiretroviral treatment.

    If you would like to find out more, please telephone 020 7188 2608/9 to speak to the clinical trials unit or email

  • Patients on antiretroviral treatment for at least six months

    • NEAT ID study
      The study is investigating the benefits of switching away from a boosted protease inhibitor (PI) to a new drug called dolutegravir on your cardiovascular health (the health of your heart). Dolutegravir has already been shown to be extremely good (and better than some HIV drugs) at keeping you viral load undetectable.
    • TaiLOR study
      A study examining the effects of Telmisartan, an angiotensin-receptor blocker, on insulin resistance.  

    If you would like to find out more, please telephone 020 7188 2608/9 to speak to the clinical trials unit or email

  • Observational/non treatment studies

    • Seroconverters
      If you had a HIV negative test within one year of your positive test then this study collects CD4 and viral load results anonymously and uses it to track changes in the HIV epicdmeinc of the last 15 years.
    • HAND study
      We are using computer tests to determine if HIV positive people might have symptoms of affected brain function and/or anxiety/depression. The information will be used to inform whether it is necessary to routinely assess HIV positive patients for the presence of anxiety/depression, decreased brain function and whether there are benefits with different antiretroviral combinations. Anyone can take part in the study.
    • PARTNER study
      A Europe-wide study for HIV positive men on HIV drugs and their HIV negative male partners designed to learn more about the risks of HIV transmission. HIV negative partners need to have an HIV test twice a year for this study.
    • aMASE
      Advancing Migrant Access to Health Services in Europe. This study examines barriers to healthcare for migrants living in England. If you were diagnosed HIV positive in the last five years and were not born in the UK then you are eligible. This is a survey which takes about 15mins to complete.
    • Heather
      People who have just been infected with HIV are given the option of storing blood in a biobank before starting ART with the possibility of being offered HIV reservoir clinical trials in the future.

Changing or cancelling your appointment

To cancel or change an appointment, please telephone the research office on: 020 7188 2608/9 or email

If you need to cancel your appointment, please tell us as soon as possible, preferably at least 48 hours in advance.

Previous studies

Read about past studies. Please note we are no longer recruiting volunteers for these trials.

  • Cog UK study

    The purpose of this study is to compare two routinely used combination anti-HIV therapies over 48 weeks and to assess if one regimen can improve the function of your brain compared to the other.

    The study will compare the following anti-HIV therapies to delay antiretroviral entry.

    1. Truvada + atazanavir + ritonavir
    2. Darunavir + ritonavir + maraviroc + lamivudine + abacavir
  • AHI study

    Investigation of a novel intervention in acute HIV infection (AHI) on long term latent HIV reservoir size. A pilot study of antiretroviral therapy plus immunoglobulin in AHI.

  • GS 0114

    The purpose of this study is to see if GS-9350 (Cobicistat) when given in combination with atazanavir and Truvada is safe and effective in reducing levels of HIV-1 in the blood of patients who are treatment-naïve (those who have not received any HIV drug treatment).

  • Photon 2

    A phase 3, open-label study to investigate the efficacy and safety of sofosbuvir plus ribavirin in chronic genotype 1, 2, 3 and 4, hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infected subjects.

  • MARCH study

    A randomised, open label study to evaluate the efficacy and safety of maraviroc (MVC) as a switch for either nucleoside or nucleotide analogue reverse transcriptase inhibitors (N(t)RTI) or boosted protease inhibitors (PI/r) in HIV-1 infected individuals with stable, well controlled plasma HIV-RNA while taking their first N(t)RTI + PI/r regimen of combination antiretroviral therapy (cART).

  • START study

    This is looking at patients with a CD4 count greater than 500 – at this level we wouldn't normally suggest starting HIV treatment. This study involves putting people on standard treatment versus monitoring them and starting treatment later as usual, to see if earlier treatment is helpful. People in this study have additional monitoring, including heart and lung testing.

Research team

Clinical research is performed in a friendly and supportive atmosphere by experienced research nurses and HIV physicians according to the highest ethical and regulatory standards of Good Clinical Practice (GCP) and in accordance with UK clinical trial regulations.

  • Team members


    Research nurses

    • Isabelle Jendrulek
    • Antonella Zucchetti
    • Margaret-Anne Bevan
    • Tammy Murray
    • Nishma Patel

    Research manager

    • Alice Sharp

    Patient representative

    • Juliet Bosa

Patient services

Useful links

Trafalgar Clinic HIV clinical trials

King's College Hospital HIV Research Centre

Take part in a clinical trial

Find out how you can take part in a clinical trial at Guy’s and St Thomas’ and what is involved.