Pain research

About our research

The Pain and Neuromodulation Academic Research Centre is based in the Pain Management Centre at St Thomas’ Hospital. The Pain Management Centre is internationally recognised as a centre of excellence in patient care and research.

Our area of interest include chronic pain conditions such as back pain, neck/shoulder pain, neuropathies and complex regional pain syndrome (CRPS). We conduct a number of clinical studies investigating both medications and devices. The aim of these studies is to improve our understanding of pain conditions and to establish new treatments for our patients.

For more information about the pain research department and what taking part in research involves please read our departmental leaflet (PDF 218Kb).

Current research

We are currently looking for volunteers to take part in the following studies. Click on the headings below to find out more and see if you might be eligible to take part and help us with research.

If you are interested in being a part of any of our research studies or would like more information please contact us directly on 020 7188 3237 or alternatively you can email PANARC@gstt.nhs.uk.

  • Device investigations

    MODULATE

    A study comparing spinal cord stimulation again placebo in the treatment of chronic low back pain in patients who have not had spinal surgery.

    Are you suitable? To take part in this study you must:

    • be aged 18 or over
    • have not had previous back surgery
    • have been diagnosed with chronic low back pain.

    DRAGON

    A study comparing the efficacy two spinal cord stimulation programmes in patients diagnosed with neuropathic pain.

    Are you suitable? To take part in this study you must:

    • be aged 18 or over
    • have been diagnosed with neuropathic pain.

    NSRBP

    A study comparing spinal cord stimulation against conventional medical management in the treatment of chronic low back pain in patients who have not had spinal surgery.

    Are you suitable? To take part in this study you must:

    • be aged 18 or over
    • have not had previous back surgery
    • have been diagnosed with chronic low back pain.

    NU-BURST

    A study investigating Burst spinal cord stimulation for the treatment of chronic neck pain.

    Are you suitable? To take part in this study you must:

    • be aged 18 or over
    • have neck pain with or without radiation to arm/shoulder/upper back.
  • Medication investigations

    KF7013-04

    A trial investigating the efficacy and safety of intravenous neridronic acid in patients with complex regional pain syndrome.

    Are you suitable? To take part in this study you must:

    • be aged 18 or over
    • have been diagnosed with CRPS.

Past research

Read about past studies. Please note we are no longer recruiting volunteers for these trials.

  • Device investigations

    SENZA MIGRAINE

    A feasibility study looking at the use of HF10 spinal cord stimulation (SCS) for the treatment of refractory chronic migraine.

    ST JUDE CRISP

    A study comparing pain relief provided by two different stimulation programmes used in spinal cord stimulator devices for the treatment of chronic low back pain.

    MEDTRONIC

    A study evaluating the safety and efficacy of different frequencies used in spinal cord stimulation in the management of failed back surgery syndrome. Read the results.

    VB2011UK Nevro

    A study exploring the effectiveness of 10 kHz high frequency spinal cord stimulation (HF10 therapy) in the treatment of chronic low back pain in patients who have not had spinal surgery. Read the results.

    RF-GENE

    A study looking at the possibility of predicting individual responsiveness to radiofrequency denervation for facet join mediated pain on the basis of specific genetic pattern.

    CA2009 Nevro

    A study exploring the effectiveness of 10 kHz high frequency spinal cord stimulation (HF10 therapy) in the treatment of chronic low back pain patients. Read the results.

  • Medication investigations

    CONVERGANCE

    A trial investigating efficacy of a drug called BIIB074 in subjects with lumbosacral radiculopathy.

    EMA401

    A trial investigating a drug called EMA401 safety and efficacy in reducing pain intensity in patients with painful diabetic neuropathy.

    MOBILE

    A trial investigating a drug called ASP5477 efficacy and safety in patients with peripheral neuropathic pain.

    LIPS

    An MRC funded trial investigating the efficacy and safety of intravenous immunoglobulin in patients with longstanding complex regional pain syndrome. Read the results.

    PL37

    A trial investigating a drug called PL37 in patients with diabetic neuropathy.

    KF7013

    A trial investigating the efficacy and safety of intravenous neridronic acid in patients with complex regional pain syndrome type 1 (CRPS-1).

    AXSOME

    A trial looking at a drug called disodium zoledronate tetrahydrate in patients with complex regional pain syndrome type 1 (CRPS-1).

    CGAW

    A trial investigating the efficacy and safety of galcanenzumab in patients with treatment resistant migraine.

    Botox

    An observational study to monitor the safety of Botox as a preventative treatment of headaches in patients with chronic migraine.

Our research team

Dr Adnan Al-Kaisy, director and clinical lead

Dr David Pang, investigator
Dr Stefano Palmisani, investigator
Dr Thomas Smith, investigator
Dr Fauzia Hasnie, investigator
Dr Giorgio Lambru, investigator
Dr Jonathan Royds, investigator

Samuel Wesley, research manager

Elizabeth Clarke, research nurse
Alba Barras, research nurse

Ramla Abuukar Abdullahi, research coordinator
Lara Monkiewicz, research coordinator

Contact us

If you are interested in being a part of any of our research studies or would like more information please contact us directly on 020 7188 3237 or email PANARC@gstt.nhs.uk.

Patient and public involvement meetings

We have an active patient and public involvement (PPI) group which meets to discuss upcoming treatments and latest developments in pain conditions. If you would like to be involved please email PANARC@gstt.nhs.uk. Here is an example of our PPI meeting slides (PDF 1MB).

More information about clinical trials

Take part in a clinical trial

Find out how you can take part in a clinical trial at Guy’s and St Thomas’ and what is involved.