Haemotology involves the diagnosis and treatment blood and bone marrow disorders. These affect the production of blood and its components, such as blood cells, haemoglobin, blood proteins, and coagulation (clotting).
Examples of blood and bone marrow disorders include haemophilia, leukaemia, and sickle cell anaemia.
Read about past studies. Please note we are no longer recruiting volunteers for this trial.
Severe Haemophilia A is a serious bleeding disorder affecting 2,000 people in the UK. Patients suffer spontaneous bleeding in their joints and muscles, and even their brain. Current treatment involves injecting coagulation Factor VIII (Factor 8) two to three times a week to control and prevent bleeding, which affects the patient’s quality of life and is expensive.
A study by our haemostasis research unit shows that adding another coagulation protein, Factor XIII (Factor 13), could significantly reduce the need for Factor VIII. A major advantage with Factor XIII is that it stays circulating in the blood for a long time, so patients would only needed to be injected once or twice a month.
Our researchers are now doing clinical trials. If they prove that Factor XIII is as good as or better than Factor VIII, it will improve quality of treatment and drastically cut the cost of treating haemophilia A by a (conservative) estimate of up to 25%, possibly within five years.
See the scientific paper.